International Research Review

International Research Review2021-03-08T11:41:45-05:00

Back-to-university checklist: books, pens, vaccine

By Alexis Palmer-Fluevog Researchers from Ontario indicate that about 80% of students enrolled at a large Canadian university between June and October 2020, prior to the availability of vaccines, intended to receive a COVID-19 vaccine once it was offered. In their recent publication in PLOS One, the researchers highlight personal perspectives around COVID-19 vaccines and explore the willingness of students to receive a vaccine. [...]

August 17, 2021|International research review|

Safety and immunogenicity of a “mix-and-match” vaccine strategy with the AstraZeneca and Pfizer-BioNTech vaccines

By Varun C. Anipindi  A new study published in The Lancet by researchers from Oxford University provides more in-depth safety and immunogenicity data to support a “mix-and-match” vaccine strategy, similar to the one currently used in Canada. Faced with vaccine supply issues and to increase the speed at which the entire population could be immunized, Canada supported a heterologous prime/boost schedule, i.e., a “mix [...]

August 17, 2021|International research review|

Breakthrough infections with the Delta variant in vaccinated individuals may be associated with lower levels of neutralizing antibodies.

By Varun C. Anipindi Emergence of variants of concern (VOCs) may potentially impact efforts to end the COVID-19 pandemic, despite the ongoing continuation of the global vaccine rollout. Here, we summarize multiple published and pre-print articles which report increasing prevalence of breakthrough infections in individuals vaccinated with Pfizer or Moderna’s mRNA vaccines. VOCs such as the Alpha and Delta variants represent the prevailing cause [...]

August 10, 2021|International research review|

Meeting the need for Long COVID policies – call for action

By Marija Djekic-Ivankovic & Mariana Gisela Bego According to a recent viewpoint in Science, around one in three people with symptomatic COVID-19 still experience symptoms 12 weeks after the onset of infection, an outcome known as Post-COVID Conditions or Long COVID. While the mechanisms at play and risk factors of Long COVID are not yet well understood, policy responses need to take into account [...]

August 10, 2021|International research review|

Life course health outcomes of children born to mothers with COVID-19

By Marija Djekic-Ivankovic Maternal COVID-19 infection has resulted in elevated rates of preterm birth and low birth weight. According to a recent publication in JAMA Pediatrics, exposure to maternal COVID-19 infection may have broader implications on newborns later in life, suggesting a potential risk for long-term health outcomes among these individuals. Given the novelty of the virus, evidence regarding long-term implications nevertheless remains lacking. [...]

August 3, 2021|International research review|

How effective are the Pfizer and the AstraZeneca vaccines against the delta variant?

By Mercedes Yanes Lane In a recent study published in the New England Journal of Medicine, researchers from the UK have estimated the effectiveness of vaccination in preventing symptomatic disease caused by the delta or alpha variants. One dose of the Pfizer or the AstraZeneca vaccine was less than 50% effective against symptomatic COVID-19 caused by delta or alpha. However, when two doses of [...]

August 3, 2021|International research review|

Long-term analysis of COVID-19 patients demonstrates durable and broad immune responses against SARS-CoV-2

By Varun C. Anipindi While scientists are striving to identify the specific protection mechanisms against SARS-CoV-2, a recent publication in Cell Reports Medicine followed a group of 254 COVID-19-recovered individuals who were infected during the first surge of COVID-19 in Seattle and Atlanta. With aims to unravel the spectrum of immunity to COVID-19 infection, authors report that these individuals mounted robust humoral and cell-mediated [...]

July 27, 2021|International research review|

Growing evidence for safety and effectiveness of mix-and-match COVID-19 vaccination

By Marija Djekic-Ivankovic Mixing COVID-19 vaccine products has been done to maximize the number of people that can be fully vaccinated in settings where vaccine availability is limited or unpredictable. Information regarding immunogenicity and safety aspects of this method is growing: two recent European studies concluded that supplementing the Oxford–AstraZeneca first dose with an mRNA vaccine as the second dose (either Pfizer–BioNTech, or Moderna) [...]

July 27, 2021|International research review|

Forecasting the future of COVID-19

By: Alexis K. Palmer-Fluevog How will the global population continue to interact with the virus in the long-term? Articles in Nature and the Journal of the American Medical Association offer several scenarios, ranging from the complete eradication of the virus to the potential for ongoing severe infections, and to the evolution of the virus, among others. While the pandemic ‘endgame’ may be hard to [...]

July 20, 2021|International research review|
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