Long COVID

Fine analysis of longitudinal immune responses to SARS-CoV-2 in vaccination: Harnessing the power of ‘Stop The Spread Ottawa’ to understand immune protection in COVID-19

Angela M. Crawley and Marc-André Langlois, Ottawa Hospital Research Institute

This research team is studying the T cell response in participants over the course of a year. We are evaluating how participants’ T cells respond to COVID-19, as well as antibodies, using a systematic approach to define correlates of protection (COP).
Research summary

Identification of microbial factors to modulate immune dysregulation and treat post-COVID-19 syndrome

Emilia Liana Falcone, Institut de recherches cliniques de Montréal

This research centers around our hypothesis that long COVID symptoms are at least in part due to microbes in the intestines caused by COVID-19 which create bacteria that leaks from the stomach and intestinal lining and moves elsewhere in the body including into the blood, resulting in persistent inflammation.
Research summary

Variants of Concern

Allison McGeer
Allison McGeer

Variants of concern: escape from infection- and vaccination-induced immunity in older adults

Anne-Claude Gingras and Allison McGeer, Sinai Health System

This team is studying to what extent the different variants circulating in Canada are efficiently neutralized in older adults’ immune systems after vaccination. It’s important to study older adults as this population group is likely to build lower levels of antibodies following vaccination and is more susceptible to severe disease.
Research summary

Intranasal multivalent vaccines targeting COVID-19 variants of concern

Jun Liu, University of Toronto

This study aims to develop multivalent vaccines, that is, vaccines which are capable of combatting more than one variant at the same time. The team is also determining the benefits of administering these vaccines by the nose, rather than with a needle.
Research summary

Mapping the Emergence and Functional Impact of Novel SARS-CoV-2 Variants

Jeff Wrana and Laurence Pelletier, Sinai Health System

This study is using data from thousands of positive COVID-19 samples to identify known and new variants. It seeks to define the impact of the mutations on the virus’ ability to infect cells and be neutralized. The team will also use next-generation sequencing to identify why VOCs are more infectious and deadly and use mathematical modelling to monitor and predict the spread and prevalence of VOCs.
Research summary

See our other funded research studies

See our other funded research studies