Published Research Papers

Published Research Papers2021-03-29T18:04:17-04:00

Publications from CITF-funded Research

Mark A Brockman, Francis Mwimanzi, Yurous Sang, Kurtis Ng, Olga Agafitei, Siobhan Ennis, Hope Lapointe, Landon Young, Gisele Umviligihozo, Laura Burns, Chanson J Brumme, Victor Leung, Julio S G Montaner, Daniel Holmes, Mari DeMarco, Janet Simons, Masahiro Niikura, Ralph Pantophlet, Marc G Romney, Zabrina L Brumme. Weak humoral immune reactivity among elderly residents of long-term care facilities following one dose of BNT162b2 mRNA COVID-19 vaccine. Posted March 24, 2021 medRxiv 2021.03.17.21253773; doi: https://doi.org/10.1101/2021.03.17.21253773

Irfan Ullah, Jérémie Prévost, Mark S Ladinsky, Helen Stone, Maolin Lu, Sai Priya Anand, Guillaume Beaudoin-Bussières, Mehdi Benlarbi, Shilei Ding, Romain Gasser, Corby Fink, Yaozong Chen, Alexandra Tauzin, Guillaume Goyette, Catherine Bourassa, Halima Medjahed, Matthias Mack, Kunho Chung, Craig B Wilen, Gregory A. Dekaban, Jimmy D. Dikeakos, Emily A. Bruce, Daniel E Kaufmann, Leonidas Stamatatos, Andrew T. McGuire, Jonathan Richard, Marzena Pazgier, Pamela J. Bjorkman, Walther Mothes, Andrés Finzi, Priti Kumar, Pradeep D. Uchil. Live imaging of SARS-CoV-2 infection in mice reveals neutralizing antibodies require Fc function for optimal efficacy. bioRxiv 2021.03.22.436337; Posted March 22, 2021. doi: https://doi.org/10.1101/2021.03.22.436337

Brunet-Ratnasingham E, Anand SP, Gantner P, Moquin-Beaudry G, Dyachenko A, Brassard N, Beaudoin-Bussières G, Pagliuzza A, Gasser R, Benlarbi M, Point F, Prévost J, Laumaea A, Niessl J, Nayrac M, Sannier G, Boutin M, Descôteux-Dinelle J, Gendron-Lepage G, Goyette G, Bourassa C, Medjahed H, Orban C, Butler-Laporte G, Morrison D, Zhou S, Nakanishi T, Laurent L, Richard J, Dubé M, Fromentin R, Rébillard R-M, Arbour N, Prat A, Larochelle C, Durand M, Richards JB, Chassé M, Tétreault M, Chomont N, Finzi A, Kaufmann DE. Integrated immunovirological profiling validates plasma SARS-CoV-2 RNA as an early predictor of COVID-19 mortality. medRxiv. 2021 Mar 20. doi: 10.1101/2021.03.18.21253907

Majdoubi A, Michalski C, O’Connell SE, Dada S, Narpala S, Gelinas J, Mehta D, Cheung C, Winkler D, Basappa M, Liu  AC, Görges M, Barakauska VE, Irvine M, Mehalko J, Esposito D, Sekirov I, Jassem AN, Goldfarb DM, Pelech S, Douek DC, McDermott AB, Lavoie PM. A majority of uninfected adults show pre-existing antibody reactivity against SARS-CoV-2. JCI Insight. 2021 Mar 15. doi: 10.1172/jci.insight.146316.

Matic NLowe CFRitchie GStefanovic ALawson TJang WYoung MDong WBrumme ZLBrumme CJLeung VRomney MG. Rapid detection of SARS-CoV-2 variants of concern identifying a cluster of B.1.1.28/P.1 variant in British Columbia, Canada. medRxiv.  2021 Mar 12. doi: 10.1101/2021.03.04.21252928

Castonguay N, Zhang W, Langlois M-A. Meta-analysis of the dynamics of the emergence of mutations and variants of SARS-CoV-2. MedRxiv preprint, 2021 March 08. doi: 10.1101/2021.03.06.21252994

Tang X, Sharma A, Pasic M, Colwill K, Birnboim Ch, Nagelkerke Nico, Bogoch I, Schultz C, Newcombe L, Slater J, Rodriguez P, Huang G, Fu SH,  Meh C, Wu ChN,  Kaul R, Langlois MA, M E, Hollander A, Eliopoulos D, Aloi B, Lambe T, AbeK, Caldwell L, Barrios-Rodiles M,  Fazel-Zarandi M, Weingust R, Wang J, Rathod B, Santhanam DR, Cho ER, Qu K, Jha S, Jha V, Suraweera W,  Wen R, Sinha SR, Gingras AC, Chakraborty P, Slutsky  AS, Jha P. COVID symptoms, seroprevalence, and mortality during the first wave of SARS-CoV-2 in Canada. Lancet. 2021 25 Jan. doi: 10.2139/ssrn.3752659.

K Wilson and C Flood. Implementing digital passports for SARS-CoV-2 immunization in Canada. CMAJ. 2021 Mar 2. 193 (10). doi: 10.1503/cmaj.210244.

Rébillard RM, Charabati M, Grasmuck C, Filali-Mouhim A, Tastet O, Brassard N, Daigneault A, Bourbonnière L, Anand SP, Balthazard R, Beaudoin-Bussières G, Gasser R, Benlarbi M, Carmena Moratalla A, Carpentier Solorio Y, Boutin M, Farzam-Kia N, Descôteaux-Dinelle J, Fournier AP, Gowing EM, Laumaea A, Jamann H, Lahav B, Goyette G, Lemaître F, Mamane VH, Prévost J, Richard J, Thai K, Cailhier JF, Chomont N, Finzi A, Chassé M, Durand M, Arbour N, Kaufmann DE, Prat A, Larochelle C. Identification of SARS-CoV-2-specific immune alterations in acutely ill patients. J Clin Invest. 2021 Feb 26:145853. doi: 10.1172/JCI145853

Nazy I, Jevtic SD, Moore JC, Huynh A, Smith JW, Kelton JG, Arnold DM. Platelet-activating immune complexes identified in critically ill COVID-19 patients suspected of heparin-induced thrombocytopenia. J Thromb Haemost. 2021 Feb 27. doi: 10.1111/jth.15283.

Papenburg J , Cheng MP , Corsini R, Caya C, Mendoza E, Manguiat K, Lindsay LF , Wood H, Drebot MA, Dibernardo A , Zaharatos G , Bazin R, Gasser R, Benlarbi M , Gendron-Lepage G, Beaudoin-Bussières G, Prévost J, Finzi A, Ndao M, Yansouni C.  Evaluation of a Commercial Culture-free Neutralization Antibody Detection Kit for 2 Severe Acute Respiratory Syndrome-Related Coronavirus-2 and Comparison with an 3 Anti-RBD ELISA Assay. MedRxiv. 2021 Feb 20. doi: 10.1101/2021.01.23.21250325.

Anand SP, Prévost J, Richard J, Perreault J, Tremblay T, Drouin M, Fournier MJ, Lewin A, Bazin R, Finzi A. High-throughput detection of antibodies targeting the SARS-CoV-2 Spike in longitudinal convalescent plasma samples. Transfusion. 2021 Feb 18. doi: 10.1111/trf.16318.

Gasser R, Cloutier M, Prévost J, Fink C, Ducas É, Ding S, Dussault N, Landry P, Tremblay T, Laforce-Lavoie A, Lewin A, Beaudoin-Bussières G, Laumaea A, Medjahed H, Larochelle C, Richard J, Dekaban GA, Dikeakos JD, Bazin R, Finzi A. Major role of IgM in the neutralizing activity of convalescent plasma against SARS-CoV-2. Cell Rep. 2021 Feb 10:108790. doi: 10.1016/j.celrep.2021.108790.

Flood C, Thomas B, Wilson K. Mandatory vaccination for health care workers: an analysis of law and policy. CMAJ. 2021 Feb 8. 193 (6). doi.org/10.1503/cmaj.202755.

Saeed S, Drews SJ, Pambrun C, Yi QL, Osmond L, O’Brien SF. SARS‐CoV‐2 seroprevalence among blood donors after the first COVID‐19 wave in Canada. Transfusion. 2021 Feb 1. doi: 10.1111/trf.16296.

Tang X, Sharma A, Pasic M, Colwill K, Birnboim Ch, Nagelkerke Nico, Bogoch I, Schultz C, Newcombe L, Slater J, Rodriguez P, Huang G, Fu SH,  Meh C, Wu ChN,  Kaul R, Langlois MA, M E, Hollander A, Eliopoulos D, Aloi B, Lambe T, AbeK, Caldwell L, Barrios-Rodiles M,  Fazel-Zarandi M, Weingust R, Wang J, Rathod B, Santhanam DR, Cho ER, Qu K, Jha S, Jha V, Suraweera W,  Wen R, Sinha SR, Gingras AC, Chakraborty P, Slutsky  AS, Jha P. COVID Symptoms, Seroprevalence, and Mortality During the First Wave of SARS-CoV-2 in Canada. doi: 10.2139/ssrn.

Anand SP, Prévost J, Nayrac M, Beaudoin-Bussières G, Benlarbi M, Gasser R, Brassard N, Laumaea A, Gong SY, Bourassa C, Brunet-Ratnasingham E, Medjahed E, Gendron-Lepage G, Goyette G, Gokool L, Morrisseau C, Bégin P, Martel-Laferrière V, Tremblay C, Richard J, Bazin R, Duerr R, Kaufmann D, Finzi A.  Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset. bioRxiv [Preprint]. 2021 Jan 25:2021.01.25.428097. doi: 10.1101/2021.01.25.428097.

Bolotin S, Tran V, Osman S, Brown KA, Buchan SA, Joh E, Deeks SL, Allen VG. SARS-CoV-2 seroprevalence survey estimates are affected by anti-nucleocapsid antibody decline. J Infect Dis. 2021 Jan 5:jiaa796. doi: 10.1093/infdis/jiaa796.

Law JC, Koh WH, Budylowski P, Lin J, Yue F, Abe KT, Rathod B, Girard M, Li Z, Rini JM, Mubareka S, McGeer A, Chan AK, Gingras AC, Watts TH, A Ostrowski M. Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile. J Immunol. 2021 Jan 1;206(1):37-50. doi: 10.4049/jimmunol.2001067.

Prévost J, Gasser R, Beaudoin-Bussières G, Richard J, Duerr R, Laumaea A, Anand SP, Goyette G, Benlarbi M, Ding S, Medjahed H, Lewin A, Perreault J, Tremblay T, Gendron-Lepage G, Gauthier N, Carrier M, Marcoux D, Piché A, Lavoie M, Benoit A, Loungnarath V, Brochu G, Haddad E, Stacey HD, Miller MS, Desforges M, Talbot PJ, Maule GTG, Côté M, Therrien C, Serhir B, Bazin R, Roger M, Finzi A. Cross-Sectional Evaluation of Humoral Responses against SARS-CoV-2 Spike. Cell Rep Med. 2020 Oct 20;1(7):100126. doi: 10.1016/j.xcrm.2020.100126.

Beaudoin-Bussières G, Laumaea A, Anand SP, Prévost J, Gasser R, Goyette G, Medjahed H, Perreault J, Tremblay T, Lewin A, Gokool L, Morrisseau C, Bégin P, Tremblay C, Martel-Laferrière V, Kaufmann D, Richard J, Bazin R, Finzi A. Decline of humoral responses against SARS-CoV-2 spike in convalescent individuals.  doi: 10.1128/mBio.02590-20.

Arora RK, Joseph A, Van Wyk J, Rocco S, Atmaja A, May E, Yan T, Bobrovitz N, Chevrier J, Cheng MP, Williamson T. SeroTracker: a global SARS-CoV-2 seroprevalence dashboard. Lancet Infect Dis. 2020 Aug. doi: 10.1016/S1473-3099(20)30631-9

Publications by CITF Members

Barton M, Papenburg J, Ulloa-Gutierrez R, Brenes-Chacon H, Yock-Corrales A, Ivankovich-Escoto G, Soriano-Fallas A, Mezerville MH, Bitnun A, Morris SK, El Tal T,  Yeh EA, Gill P, Laxer R, Nateghian A, Aski BH, Manafif A, Lefebvre M-A, Caya C, Cooke  S, Dewan T, Restivo L, Viel-Thériault I, Trajtman A, Dwilow R, Bullard J, Sadarangani M, Roberts A, Le Saux N, Bowes J, Wong JK, Purewal R, Lautermilch J, Leifso K, Foo C, Newhook LA, Bayliss A, Petel D, Robinson J on behalf of the Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC). Multicenter cohort study of children hospitalized with SARS-CoV-2 infection. MedRxiv. 2021 Feb 23. doi.org/10.1101/2021.02.19.21251340.

Ismail SJ, Zhao L, Tunis MC, Deeks SL, Quach C. Key populations for early COVID-19 immunization: preliminary guidance for policy. CMAJ. 2020 Nov 30;192(48):E1620-32. doi: 10.1503/cmaj.202353.

Vijh R, Ghafari C, Hayden A, Schwandt M, Sekirov I, Morshed M, Levett P, Krajden M, Boraston S, Daly P, Lysyshyn M, Harding J, McLennan M, Chahil N, Mak A, McKee G. Serological survey following SARS-COV-2 outbreaks at long-term care facilities in metro Vancouver, British Columbia: Implications for outbreak management and infection control policies. 18:S0196-6553(20)30927-5. doi: 10.1016/j.ajic.2020.10.009.

Kohler PP, Kahlert CR, Sumer J, Flury D, Güsewell S, Leal-Neto OB, Notter J, Albrich WC, Babouee Flury B, McGeer A, Kuster S, Risch L, Schlegel M, Vernazza P. Prevalence of SARS-CoV-2 antibodies among Swiss hospital workers: Results of a prospective cohort study. Infect Control Hosp Epidemiol. 2020 Oct 8:1-5. doi: 10.1017/ice.2020.1244.

Isho B, Abe KT, Zuo M, Jamal AJ, Rathod B, Wang JH, Li Z, Chao G, Rojas OL, Bang YM, Pu A, Christie-Holmes N, Gervais C, Ceccarelli D, Samavarchi-Tehrani P, Guvenc F, Budylowski P, Li A, Paterson A, Yue FY, Marin LM, Caldwell L, Wrana JL, Colwill K, Sicheri F, Mubareka S, Gray-Owen SD, Drews SJ, Siqueira WL, Barrios-Rodiles M, Ostrowski M, Rini JM, Durocher Y, McGeer AJ, Gommerman JL, Gingras AC. Persistence of serum and saliva antibody responses to SARS-CoV-2 spike antigens in COVID-19 patients. Sci Immunol. 2020 Oct 8;5(52):eabe5511. doi: 10.1126/sciimmunol.abe5511.

Abe KT, Li Z, Samson R, Samavarchi-Tehrani P, Valcourt EJ, Wood H, Budylowski P, Dupuis AP 2nd, Girardin RC, Rathod B, Wang JH, Barrios-Rodiles M, Colwill K, McGeer AJ, Mubareka S, Gommerman JL, Durocher Y, Ostrowski M, McDonough KA, Drebot MA, Drews SJ, Rini JM, Gingras AC. A simple protein-based surrogate neutralization assay for SARS-CoV-2. JCI Insight. 2020 Oct 2;5(19):e142362. doi: 10.1172/jci.insight.142362.

Cheng MP, Yansouni CP, Basta NE, Desjardins M, Kanjilal S, Paquette K, Caya C, Semret M, Quach C, Libman M, Mazzola L, Sacks JA, Dittrich S, Papenburg J. Serodiagnostics for Severe Acute Respiratory Syndrome–Related Coronavirus 2: A Narrative Review. Ann Intern Med. 2020 Sep 15;173(6):450-460. doi: 10.7326/M20-2854.

Van Caeseele P, Bailey D, Forgie SE, Dingle TC, Krajden M. SARS-CoV-2 (COVID-19) serology: implications for clinical practice, laboratory medicine and public health. CMAJ. 2020 Aug 24;192(34):E973-E979. doi: 10.1503/cmaj.201588.

Anderson G, Frank JW, Naylor CD, Wodchis W, Feng P. Using socioeconomics to counter health disparities arising from the covid-19 pandemic. BMJ. 2020 Jun 8;369:m2149. doi: 10.1136/bmj.m2149.

Cheng MP, Papenburg J, Desjardins M, Kanjilal S, Quach C, Libman M, Dittrich S, Yansouni CP. Diagnostic testing for severe acute respiratory syndrome–related coronavirus 2: a narrative review. Ann Intern Med. 2020 Jun 2;172(11):726-734. doi: 10.7326/M20-1301.

Go to Top