Pediatric Studies

Active surveillance for COVID-19 vaccine safety and effectiveness among Canadian children: A Canadian Immunization Monitoring Program ACTive (IMPACT) Project

Karina Top and Shaun Morris, Dalhousie University / Canadian Pediatric Society

This study aims to track the safety and effectiveness of COVID-19 vaccines in children and youth as they become approved for use in this age group. Researchers are also studying whether vaccination is linked to fewer children and adolescents being admitted to hospital for COVID-19 and fewer cases of the disease overall.
Research summary

Rapid research in the CHILD Cohort to inform Canada’s response to the COVID-19 pandemic

Meghan Azad and Padmaja Subbarao, University of Manitoba

Building off the CHILD Cohort Study which tracks 3,500 families in British Columbia, Alberta, Manitoba, and Ontario, this study aims to provide real-time data to public health authorities about infection, symptoms, transmission, and immunity in 12,000 Canadians (CHILD children, siblings, parents) in these four provinces.
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Safe return to school, work, and play: The TARGet Kids! COVID-19 study of children and families

Jonathon Maguire, Unity Health Toronto

This study pivots TARGet Kids! — Canada’s largest ongoing children’s study — to focus on gathering high-quality, real-time data to monitor, quantify, and characterize COVID-19 infection among children and parents.
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The SPRING Study: SARS-CoV-2 infection in children and young adults in British Columbia

Manish Sadarangani, University of British Columbia

The SPRING Study aims to understand the true rates of SARS-CoV-2 infection in children and young adults in British Columbia, most notably, by including information from children with asymptomatic infection.
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The EnCORE Study: How many children and teens in Montreal have been infected with SARS-CoV-2?

Kate Zinszer, Université de Montréal

The EnCORE Study is a research project estimating how many young people in Montreal have been infected with SARS-CoV-2. Specifically, they are studying 2- to 17-year-olds in daycares, elementary schools, and high schools randomly selected in four Montreal neighbourhoods.
Research summary Results Study website View study on

A Prospective Pan-Canadian Cohort Assessment of SARS-CoV-2 Variant of Concern Disease Severity and Association with Long-Term Symptoms in Children

Stephen Freedman, University of Calgary

We are extending and expanding two ongoing COVID-19 studies to collect acute and long-term data on children. We are following children who test positive and negative for SARS-CoV-2 in emergency departments and will compare whether certain variants lead to a greater disease severity. We will also quantify the development of long-term symptoms (long COVID) in children with COVID-19.
Research summary

From idea to reality: COVID-19 Vaccination for Children and Youth

Jonathon Maguire and Catherine S. Birken, Unity Health Toronto

This study builds on work with TARGet Kids! to understand COVID-19 vaccine effectiveness and safety among 2,000 children and youth (0 to 16 years old), and their parents. The team is looking at COVID-19 vaccine uptake and is working to understand COVID-19 vaccine hesitancy and decision-making among parents and healthcare providers in order to inform vaccination policies.
Research summary

Post COVID hyperinflammation (MIS-C): A syndrome beyond the name

Rae S. M. Yeung, Hospital for Sick Children (SickKids) Research Institute

Some children who have had COVID-19 infection develop Multisystem Inflammatory Syndrome in Children (MIS-C), an uncontrolled post-COVID-19 inflammation. This study is using machine learning and artificial intelligence strategies to analyze and integrate complex biologic and clinical data in order to rapidly diagnose MIS-C and identify the children at highest risk.
Research summary

See our other funded research studies

See our other funded research studies