CITF Research Results

CITF Research Results2021-10-12T16:15:35-04:00

A comprehensive review of international vaccine certificate programs for COVID-19

Vaccine certificates or "passports" are becoming more commonplace, with access to restaurants, event venues, and even workplaces increasingly dependent on proof of vaccination against COVID-19. To better understand how different jurisdictions are implementing digital vaccine certificates, researchers from the Ottawa Hospital Research Institute, including CITF-funded researcher Dr. Kumanan Wilson, performed a review of available literature to identify vaccine certificate policies being put into effect [...]

October 19, 2021|Other|

Antibody responses to COVID-19 vaccines in people living with HIV

Researchers Drs. Zabrina Brumme and Mark Brockman from the BC Centre for Excellence in HIV/AIDS and Simon Fraser University have determined that antibody responses following one COVID-19 vaccine dose are modestly lower in people living with HIV compared to individuals without HIV. However, they report that the discrepancy disappears after the second dose. These findings, available in preprint and therefore not yet peer-reviewed, emerge [...]

October 12, 2021|Higher risk due to health condition|

‘Made-in-Canada’ assays perform well to measure seroprevalence

Despite the many assays available to test for SARS-CoV-2 antibodies, a gold standard has not yet been established. In an article now published in PLOS ONE, CITF Testing Working Group members Dr. Anne-Claude Gingras from the University of Toronto, and Dr. Steven Drews from Canadian Blood Services, evaluate multiple testing platforms and the concordance between test results in this CITF-funded study. Percentage values in [...]

October 5, 2021|Optimization of immunologic testing|

Study finds immune cells recognizing SARS-CoV-2 in tissue predating the pandemic

CITF-funded researchers Drs. Götz Ehrhardt and Mario Ostrowski from the University of Toronto set out to determine whether their pediatric tissue samples from 2015-16 contained signs of immunity to SARS-CoV-2. They discovered immune cells and antibodies in the tonsils that could specifically recognize the virus’ spike protein. The study provides some helpful insights as to why children are better adept at clearing SARS-CoV-2 infection. [...]

October 5, 2021|Immune science|

mRNA vaccines administered with an extended interval between doses elicit strong SARS-CoV-2 antibody responses after two doses

Findings from a real-world vaccination study composed of seniors residing in long-term care facilities were recently released in preprint, therefore not yet peer-reviewed, on behalf of investigators from the CITF-funded study UNCoVER (including Dr. Donald Vinh, Research Institute of the McGill University Health Centre (RI-MUHC) and Dr. Marc-André Langlois, University of Ottawa) and the CITF Secretariat (Dr. Bruce Mazer, Associate Director, Strategy, affiliated with [...]

October 5, 2021|Long-term care & seniors|

Tracking health events after vaccination: latest results from CANVAS-COVID

The CANVAS-COVID study, funded by the CITF/Vaccine Surveillance Reference Group (VSRG), has collected self-reported information on health events following vaccination in more than one million Canadians so far. The core findings indicate that the incidence of serious side effects, emergency room visits, and hospitalizations following COVID-19 vaccination remain exceedingly rare. Results from the CANVAS-COVID study are updated weekly on their website and can be accessed [...]

September 21, 2021|General vaccine surveillance|

COVID has led to changes in the sexual behavior and access to healthcare among gay, bisexual, and other men who have sex with men (GBM)

Gay, bisexual, and other men who have sex with men (GBM) often experience significant health disparities that may act as barriers to needed health services. As part of their CITF-funded research, Dr. Daniel Grace from the University of Toronto’s Dalla Lana School of Public Health and Dr. Nathan Lachowsky from the University of Victoria, along with colleagues from the ongoing Engage study, sought to [...]

September 21, 2021|Geographic & priority populations, LGBTQ2+|

Older adults likely remain at higher risk for COVID-19 − particularly infections caused by variants of concern − even after vaccination

In a recent CITF-funded pre-print, therefore not yet peer-reviewed, Drs. Mark Brockman and Zabrina Brumme from Simon Fraser University and Dr. Marc Romney from the University of British Columbia studied immune responses following COVID-19 vaccination in over 150 adults aged 24-98 years. They found that although two doses of the mRNA vaccines provide excellent protection against SARS-CoV-2, significantly weaker vaccine-induced immune responses were recorded [...]

September 14, 2021|Immune science|

Prevalence of SARS-CoV-2 antibodies in Alberta, pre-vaccine roll out

In this study partially funded by the CITF and published in Microbiology Spectrum, researchers from Alberta Precision Laboratories collected blood samples from June 2020 to January 2021 to determine the prevalence of SARS-CoV-2 antibodies in Alberta, by assessing a total of 93,993 individual patient samples. While the prevalence of antibodies in June 2020 was very low (0.92%), prevalence increased to 4.63% in January 2021. [...]

September 14, 2021|Seroprevalence studies|
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