The methodology of the CHILD sub-study to examine the effect of SARS-CoV-2 infection on children
The study design and cohort profile of a CITF-funded study have been published in Epidemiology and Health. The research aimed to examine the prevalence and predictors of SARS-CoV-2 infection and transmission, as well as the predictors of the health and psychosocial impact of the COVID-19 pandemic, among Canadian children and their families.
Blanket SARS-CoV-2 screening among those admitted to hospital for non-COVID-19 conditions not worthwhile back in 2020
A CITF-funded study, published in BMJ Open, found that universal COVID-19 screening among adults admitted to hospital over two waves in 2020 with a diagnosis unrelated to COVID-19 had a low diagnostic yield, meaning universal screening, at the time, would not have been justifiable as a blanket policy.
A high rate of successful intubation and a low risk of related adverse events were observed during the COVID-19 pandemic
A CITF-funded study, published in the Canadian Journal of Emergency Medicine, found that intubation was completed successfully on the first try in 94% of cases for both COVID-19 and non-COVID-19 patients presenting to the emergency department.
Canadian healthcare workers assisting COVID-19 patients had higher anxiety and depression scores than pre-pandemic
A CITF-funded study, published in the Journal of Occupational and Environmental Medicine, found that healthcare workers (HCWs) assisting patients with COVID-19 exhibited clinically significant scores for anxiety and depression and were more likely to report the use of sleep medications, compared to pre-pandemic.
Patients with NDD-CKD exhibit a strong humoral immune response after three COVID-19 mRNA vaccines
A CITF-funded proof-of-principle study, published in the Canadian Journal of Kidney Health and Disease, found that patients with non-dialysis-dependent chronic kidney disease (NDD-CKD)—a typically understudied population— had high seropositivity rates for anti-spike and anti-RBD after three doses of an mRNA COVID-29 vaccine.
Longer dose-intervals in COVID-19 vaccine series produced a more robust antibody response
A CITF-supported study, published in Frontiers in Immunology, found that delaying the second dose of an mRNA COVID-19 vaccine beyond approximately three months produced a more robust antibody response, despite this being a longer timeframe than was recommended by the vaccine manufacturers.
High avidity anti-N IgG antibodies detect SARS-CoV-2 reinfections with higher specificity compared to anti-N IgG serum levels alone
A CITF-funded proof-of-principle study, published in the Journal of Infectious Diseases, found that high avidity anti-nucleocapsid (anti-N) IgG antibodies detect SARS-CoV-2 reinfections with higher specificity compared to solely measuring anti-N IgG serum levels.
Understanding human rights legal considerations in vaccination mandates for businesses
A commentary by a CITF-funded researcher, published by the C.D. Howe Institute, discusses the differences in implementing vaccination mandates in businesses vs. in government sectors.
SARS-CoV-2 wastewater signal to clinical cases ratio could complement clinical case counts and wastewater signals as individual metrics
A CITF-funded study, published in Science of the Total Environment, demonstrated that the ratio of SARS-CoV-2 wastewater signals to clinical cases (WC ratio) would add more value to wastewater-based surveillance (WBS).