Immune science

Immune cell analysis reveals that the amount of SARS-CoV-2 in the blood is a strong predictor of mortality

As SARS-CoV-2 continues to cause worldwide mortality, it has become increasingly important to define molecular markers that can identify individuals at risk of developing severe COVID-19, and even death. This could help in determining early preventive measures for improved patient outcomes. In a recent pre-print and therefore not yet peer-reviewed, CITF-funded researchers Drs. Daniel [...]

2021-03-29T20:47:05-04:00March 30, 2021|Immune science|

Using a glowing SARS-CoV-2 virus and mice to explain how antibodies protect from infection and severe disease

An international multisite research collaboration, including CITF-funded researcher Dr. Andrés Finzi from the Université de Montréal, used genetically modified mice that mimic COVID-19 disease in humans to study how antibodies from people who have recovered from COVID-19 could prevent severe disease in other people. The authors concluded that these antibodies were effective in not [...]

2021-08-31T10:50:38-04:00March 30, 2021|Immune science|

Why do some people experience mild COVID-19 symptoms and others have severe illness? Pre-existing antibodies could explain the range of COVID-19 illness

CITF-funded researcher Dr. Pascal Lavoie from the University of British Columbia and his collaborators are suggesting that the presence of antibodies to SARS-CoV-2 may not necessarily indicate a previous infection. Using highly sensitive tests, they discovered pre-existing antibodies to SARS-CoV-2 in many uninfected adults. The study was funded in part by the COVID-19 Immunity [...]

2021-03-23T10:58:27-04:00March 23, 2021|Immune science|

A novel mechanism leading to blood clot formation found in severely ill COVID-19 patients

Dr. Ishac Nazy and the McMaster Platelet Immunology Laboratory have found some of the reasons behind why some patients with severe COVID-19 have blood clots. The team found that blood from critically ill COVID-19 patients contains molecules that can activate cells involved in blood clotting. This study was supported by the Canadian Institutes of [...]

2021-03-23T10:19:07-04:00March 23, 2021|Immune science|

Systematic examination of antigen-specific recall T cell responses to SARS-CoV-2 versus influenza virus reveals a distinct inflammatory profile

Researchers at the University of Toronto, published in the Journal of Immunology, shed light on what is happening in the body may help to explain why patients with SARS-CoV-2 have more severe inflammation and lung tissue damage than patients suffering from regular seasonal influenza virus.

2021-02-25T17:28:49-05:00December 17, 2020|Immune science|
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