Immune science

The supervised RF-PHATE data visualization method demonstrates clearer qualitative and quantitative insights compared to popular unsupervised data visualization methods

A CITF-funded study, published in preprint and not yet peer-reviewed, introduced a data visualization method called RF-PHATE, which was able to generate low-dimensional visualizations highlighting relevant data relationships while disregarding extraneous factors.

2023-12-08T14:35:48-05:00December 8, 2023|Immune science|

Two COVID-19 vaccine doses were well-tolerated, safe and highly immunogenic

A CITF-funded study, published in BMJ Open, offers yet more evidence that COVID-19 vaccines are safe and effective. The study looked at the initial two COVID-19 vaccine doses and found they were safe, well-tolerated, and highly immunogenic across a broad spectrum of vaccine recipients, including those working in public-facing environments.

2023-11-27T11:46:28-05:00November 24, 2023|Immune science|

High-density peptide array helps identify that selective pressure for immune evasion occurs upon transmission

A CITF-funded study, published in iScience, found that transmission between hosts leads to mutations that cause immune evasion (when the immune system does not recognize a virus and does not mount a fight). The study also offered more evidence that exposure to other seasonal human coronaviruses (hCoV) helps develop a better immune response to SARS-CoV-2.

2023-11-13T10:14:22-05:00November 12, 2023|Immune science|

New vaccines in development, including a trivalent vaccine, trigger strong immune responses against all SARS-CoV-2 variants in animal models

A CITF-funded study, published in iScience, developed four spike-based vaccines against the SARS-CoV-2 virus and measured antibody and cellular responses. All four – one based on the wildtype (original strain), one based on Beta, one based on Delta and a trivalent vaccine combining all three – produced a strong neutralizing antibody response in an animal model against all SARS-CoV-2 variants, including against the Omicron variant.

2023-10-27T11:10:15-04:00October 27, 2023|Immune science|

Omicron breakthrough infection instills higher and more broadly neutralizing immune responses against SARS-CoV-2 variants than a booster dose alone

A CITF-funded study, published as a preprint and not yet peer-reviewed, found that individuals with two vaccine doses and an Omicron breakthrough infection produced higher salivary SARS-CoV-2 IgA antibodies against Spike and RBD than individuals with three vaccine doses and no breakthrough infection.

2023-10-20T11:43:04-04:00October 14, 2023|Immune science|

Hybrid immunity conferred stronger immune responses in children and adults than vaccination alone

A CITF-supported study, published in preprint and not yet peer-reviewed, found that two doses of mRNA vaccine (Pfizer or Moderna) produce robust antibody responses three months post-vaccination in both children and adults. Additionally, hybrid immunity (immunity derived from the combination of SARS-CoV-2 infection and vaccination) conferred stronger immune responses in both age groups when compared to vaccination alone.

2023-10-02T10:14:19-04:00October 2, 2023|Immune science|
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