Immune science

A viral-vector COVID-19 vaccine candidate under development

Researchers, including Dr. Ryan Troyer from the University of Western Ontario, who is funded by the CITF, are developing a new vaccine that uses a harmless virus-based delivery vehicle. This approach enables the SARS-CoV-2 spike protein to be presented to the immune system, thereby training it to recognize and prevent SARS-CoV-2 infection. The vaccine [...]

2022-01-10T10:41:33-05:00January 10, 2022|Immune science|

An intranasal vector vaccine can be used to mount protective responses against SARS-CoV-2 in the respiratory tract

A team led by CITF-funded researcher Dr. Jun Liu at the University of Toronto have demonstrated that a novel intranasal COVID-19 vaccine product can induce robust mucosal and systemic immune responses in a mouse model of SARS-CoV-2 infection. This is significant because existing vaccines, which are highly effective at inducing antibodies systemically (in the [...]

2021-12-21T08:56:02-05:00December 20, 2021|Immune science|

Older adults likely remain at higher risk for COVID-19 even after vaccination

In a CITF-funded study originally released as a preprint and now published in the Journal of Infectious Diseases, Drs. Mark Brockman and Zabrina Brumme from Simon Fraser University and Dr. Marc Romney from the University of British Columbia examined immune responses following COVID-19 vaccination in over 150 adults aged 24-98 years. They found that [...]

2021-12-13T15:57:45-05:00December 13, 2021|Immune science|

Immune cell analysis reveals the amount of SARS-CoV-2 in blood is a strong predictor of mortality

CITF-funded researchers Drs. Daniel Kaufmann, Andrés Finzi and Nicolas Chomont from the Université de Montréal and the Université de Montréal hospital research centre (CRCHUM), along with their collaborators, found that the amount of viral mRNA  in the blood can help identify hospitalized patients who will suffer severe COVID-19, and even death. The discovery of [...]

2021-12-13T14:35:27-05:00December 13, 2021|Immune science|

Previous infection with common cold seasonal coronavirus may help protect against COVID-19

Nearly everyone has been exposed to the highly prevalent seasonal coronaviruses responsible for the common cold. But could this exposure induce antibodies that also recognize certain proteins of the SARS-CoV-2 virus? A study led by University of Ottawa researcher Dr. Marc-André Langlois, now published in EBio Medicine, proposes that some individuals previously infected with [...]

2021-12-06T12:42:32-05:00December 6, 2021|Immune science|

Study finds immune cells recognizing SARS-CoV-2 in tissue predating the pandemic

CITF-funded researchers Drs. Götz Ehrhardt and Mario Ostrowski from the University of Toronto set out to determine whether their pediatric tissue samples from 2015-16 contained signs of immunity to SARS-CoV-2. They discovered immune cells and antibodies in the tonsils that could specifically recognize the virus’ spike protein. The study provides some helpful insights as [...]

2021-10-05T10:23:36-04:00October 5, 2021|Immune science|

Older adults likely remain at higher risk for COVID-19 − particularly infections caused by variants of concern − even after vaccination

In a recent CITF-funded pre-print, therefore not yet peer-reviewed, Drs. Mark Brockman and Zabrina Brumme from Simon Fraser University and Dr. Marc Romney from the University of British Columbia studied immune responses following COVID-19 vaccination in over 150 adults aged 24-98 years. They found that although two doses of the mRNA vaccines provide excellent [...]

2021-09-13T23:31:41-04:00September 14, 2021|Immune science|

COVID-19 vaccines generate detectable specific antibodies in saliva

It is known that existing COVID-19 vaccines trigger the production of neutralizing antibodies in blood. However, since SARS-CoV-2 first enters the body via the upper respiratory tract, if antibodies were located in this area, they could potentially start fighting the virus immediately. A recent preprint, not yet peer-reviewed, examines whether COVID-19 vaccines induce antibodies [...]

2021-08-17T11:55:38-04:00August 17, 2021|Immune science|

Poorer neighbourhoods and racialized communities continue to lag behind in vaccine coverage: latest Canadian Blood Services results

The gap between the rates of COVID-19 infection and vaccination among racialized and non-racialized Canadians continues to exist, as does the gap between Canadians from lower- and higher-income neighbourhoods. The CITF-funded Canadian Blood Services Serosurveillance Study has released its latest report for the month of May 2021. While the latest data show that the [...]

2021-08-10T16:01:33-04:00August 10, 2021|Immune science|
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