CITF Research Results

CITF Research Results2021-10-12T16:15:35-04:00

Vaccine-induced seroprevalence hits highest level to date, yet early fourth wave hitting those most at-risk: Canadian Blood Services August report

96% of Canadian blood donors have evidence of SARS-CoV-2 antibodies, primarily due to vaccination, a rate that has increased from 91% in June and 95% in July. This according to Canadian Blood Services’ 13th seroprevalence report, covering data from August 2021. Nonetheless, targeted efforts to alleviate infection burden and promote vaccine uptake are still required amongst racialized donors and those living in lower-income neighbourhoods, [...]

November 19, 2021|General population studies|

Incarcerated individuals face an increased risk of acquiring COVID-19

Congregate settings (such as prisons, long-term care homes) allow for the rapid spread of COVID-19. As part of her CITF-funded study in three provincial prisons in Quebec, Dr. Nadine Kronfli from the Research Institute of the McGill University Health Centre found that of the 1,100 incarcerated men sampled, 22% were seropositive for a previous SARS-CoV-2 infection. These findings were recently released in a Lancet [...]

November 12, 2021|Geographic & priority populations|

One in five vaccinated long-term care residents at risk of COVID-19 because of low antibody levels, supporting need for booster shots

Findings from a CITF-funded study led by Drs. Andrew Costa and Dawn Bowdish at McMaster University helped inform the federal government’s decision to recommend a third dose of COVID-19 vaccine for long-term care residents. More than 97% of residents produced an initial antibody response to vaccination that is likely to provide protection against the virus. However, three to five months following the second dose, [...]

November 12, 2021|Long-term care & seniors|

COVID Infections in children and teens continue to rise, study finds

CITF-funded researcher Dr. Kate Zinszer, from the Université de Montréal, and her EnCORE study team have released additional preliminary, non-peer reviewed results indicating a marked increase in the number of Montreal youth aged 2 to 17 with antibodies due to a SARS-CoV-2 infection in recent months. They found that 9.7% of participants had antibodies to SARS-CoV-2 between May and August 2021, whereas 5.8% had [...]

November 12, 2021|Pediatrics|

Mental health and life satisfaction declined among Canadian paramedics during the COVID-19 pandemic

CITF-funded researchers Dr. Tracy Kirkham and PhD student Christopher MacDonald from the University of Toronto and colleagues found that the COVID-19 pandemic had negative effects on Canadian paramedics in 2021 including reduction in life satisfaction, mental and physical health, and the ability to cope with stress. The impacts were greater among female paramedics and/or those with risk factors for underlying mental disorders. These preliminary [...]

November 8, 2021|Healthcare workers|

Low COVID-19 infection rate among Canadian dentists is reassuring to the profession

Due to the nature of dentistry, dental care settings have the potential to be high-risk environments for the spread of COVID-19. A study published in The Journal of the American Dental Association, and led by CITF-supported investigator Dr. Sreenath Madathil from McGill University, found that infection was lower among dentists (1084 per 100,000) than within the general Canadian population (1864 per 100,000). The authors followed [...]

November 5, 2021|Healthcare workers|

Designing serological assays with high diagnostic potential

In a not-yet peer-reviewed preprint, CITF-funded investigator Dr. Andrei Drabovich and colleagues from the University of Alberta, designed and evaluated the performance of serological diagnostics, used to measure the presence of SARS-CoV-2 antibodies. The particular assays studied, known as immunoprecipitation - parallel reaction monitoring (IP-PRM) and immunoprecipitation - selected reaction monitoring (IP-SRM), use a combination of two common laboratory techniques, ELISA and mass spectrometry [...]

November 2, 2021|Optimization of immunologic testing|

Explaining the limited utility of convalescent plasma from the first phase of the COVID-19 pandemic in treating those newly infected

The continued persistence of SARS-CoV-2 infections in predominantly unvaccinated individuals has meant a continued need for therapeutics to treat those hospitalized with COVID-19. Convalescent plasma containing SARS-CoV-2 neutralizing antibodies from recovered individuals is one therapy option but has been controversial. A new publication in Transfusion by CITF-funded researchers Drs. Steven Drews and Sheila O’Brien of Canadian Blood Services assesses why plasma collected from the [...]

October 29, 2021|Other|

A Canadian platform to study the antibody response to SARS-CoV-2 infection and vaccination

A group of Canadian researchers has developed a set of standardized, high-throughput serological assays to detect antibodies against SARS-CoV-2. Multiple studies estimating the seroprevalence of various populations in Canada – including over half of those funded by the CITF – use this platform, making it possible to harmonize and compare their results nationwide. In a preprint, not yet peer-reviewed, and partly funded by the [...]

October 29, 2021|Optimization of immunologic testing|
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